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Rather, the most important clue to the diagnosis of melanoma is effacement of dermal architecture by areas of confluent melanocytic growth

A smart approach is to treat hair and nail changes as a signal to review the basics: protein intake, iron status (especially ferritin), thyroid function when appropriate, and overall calorie adequacy

Specificity is therefore an important performance characteristic and this can be achieved by selecting validated antibodies that are highly specific for the analyte